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KMID : 0361120030170010034
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Korean Journal of Transplantation
2003 Volume.17 No. 1 p.34 ~ p.42
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Association of Polymorphisms in the IL-10 and IFN-gamma Genes with Allograft Dysfunction Following Kidney Transplantation in Koreans
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노은연/Eun Youn Roh
박명희/박혜진/하종원/김상준/안규리/Myoung Hee Park/Hye Jin Park/Jong Won Ha/Sang Joon Kim/Cu Rie Ahn
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Abstract
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PURPOSE: IL-10 and IFN-gamma are amongst important cytokines, which are thought to have influence on organ transplantation outcome. The aim of this study was to investigate the IL-10 and IFN-gamma gene polymorphisms in Koreans, and their association
with renal transplantation outcome. METHODS: Three SNP sites (-1082 G/A, -819 C/T, -592 C/A) of IL-10 promoter region and CA repeats in intron 1 of IFN-gamma gene were analyzed using PCR-single strand conformation polymorphism (SSCP) and direct
sequencing methods in 73 controls and 164 kidney allograft recipients. Association between polymorphisms of these genes and transplantation outcome was analyzed using chi square test or Fisher's exact test. RESULTS: The allele frequencies of the IL-10
and IFN-gamma genes showed no significant differences between the control and patient groups. The frequencies of IL-10 and IFN-gamma high producer alleles were markedly lower than those of Caucasians. The incidence of multiple acute rejection episodes
was higher in IL-10 low producer (-1082 AA) than intermediate producer (-1082 GA) group (8.6% vs 0%), and in IFN-gamma high producer ([CA](12) positive) than low producer ([CA](12) negative) group (11.9% vs 6.6%). The incidence of chronic renal
allograft dysfunction was lower in IL-10 intermediate producer than low producer group (7.7% vs 18.0%), and also lower in the combination of IL-10 intermediate/IFN-gamma low producer type than in other combinations (0% vs 18.2%). However, all these
differences were not statistically significant. CONCLUSION: IL-10 and IFN-gamma have little influence on renal transplantation outcome in Koreans, probably due to quite limited polymorphisms of these genes in this population. The results of this study
would be useful as basic data for renal transplantation in Koreans.
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KEYWORD
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